Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/551
Type: Artigo de periódico
Title: Effect of a Pool of Peptides Isolated from Crotalus durissus terrificus (South American Rattlesnake) Venom on Glucose Levels of Mice Fed on a High-Fat Diet
Author: MARTINS-SANTOS, M. E. S.
RESENDE, R. R.
PINTO, F. C. H.
SOARES, A. M.
MARANGONI, S.
OLIVEIRA, E.
ALBERICIO, F.
SILVA, S. L. Da
Abstract: This study investigated the effect of a pool of peptides, isolated from venom of Crotalus durissus terrificus (South American rattlesnake) on glucose concentration in C57BL/6 mice fed on a high-fat diet for 6 weeks. The pool of peptides (molecular mass around of 10 kDa) was obtained using a MidJet apparatus with a cartridge of 10 KDa. The peptide pool was injected intraperitoneally in mice in a single dose (0.5 mg/animal) or multiple doses (0.2 mg/dose). After predetermined times (30, 60, 90 and 120 min) post injections, venous blood samples were collected for enzymatic measurement of serum glucose using a commercial glucose kit (glucose oxidase method). High-fat fed mice showed an increase in blood glucose concentration, in comparison with mice fed on the chow diet. Thirty minutes after a single dose of the peptide pool, high-fat fed animals showed a significant decrease (similar to 47%) in glycemia. However, the glucose level increased again at 60 and 120 min. Conversely, after multiple injections of the pool of peptides administered every 30 min, the blood glucose concentration in the high-fat mice was significantly decreased (similar to 37%) and remained at low levels until 120 min. These results suggest that the tested pool of peptides from Crotalus durissus terrificus contained a peptide (or peptides) with a beneficial role on glucose-lowering action of high-fat fed mice.
Subject: Bioactive peptides
Crotalus durissus terrificus
Snake venom
Hyperglycemia
Glucose
Country: Estados Unidos
Editor: SPRINGER
Citation: INTERNATIONAL JOURNAL OF PEPTIDE RESEARCH AND THERAPEUTICS, v.17, n.3, p.225-230, 2011
Rights: fechado
Identifier DOI: 10.1007/s10989-011-9261-0
Address: http://dx.doi.org/10.1007/s10989-011-9261-0
http://apps.isiknowledge.com/InboundService.do?Func=Frame&product=WOS&action=retrieve&SrcApp=EndNote&UT=000293236200009&Init=Yes&SrcAuth=ResearchSoft&mode=FullRecord
Date Issue: 2011
Appears in Collections:IB - Artigos e Materiais de Revistas Científicas

Files in This Item:
There are no files associated with this item.


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.