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Type: Artigo de periódico
Title: Asymmetric bioreduction of ethyl 3-halo-2-oxo-4-phenylbutanoate by Saccharomyces cerevisiae immobilized in Ca-alginate beads with double gel layer
Author: Milagre, HMS
Milagre, CDF
Moran, PJS
Santana, MHA
Rodrigues, JAR
Abstract: The asymmetric bioreduction of ethyl 3-halo-2-oxo-4- phenylbutanoate was studied for several microorganisms and especially for Saccharomyces cerevisiae. The highest chemical yield (90%), de (70%) and ee (96-99%) were obtained with S. cerevisiae immobilized in calcium alginate beads with double gel layers, and reaction conditions were optimized by changing matrix of immobilization, concentration of substrate, and feeding with glucose as electron donor. The entrapment of cells with double gel layers was fundamental to achieve high enantio- and diastereoselectivity.
Country: EUA
Editor: Amer Chemical Soc
Rights: fechado
Identifier DOI: 10.1021/op0502497
Date Issue: 2006
Appears in Collections:Artigos e Materiais de Revistas Científicas - Unicamp

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