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Type: Artigo de periódico
Title: Astrocyte reactivity influences the number of presynaptic terminals apposed to spinal motoneurons after axotomy
Author: Emirandetti, A
Zanon, RG
Sabha, M
de Oliveira, ALR
Abstract: Although synaptic plasticity is a widespread phenomenon, the underlying mechanisms leading to its occurrence are virtually unknown. In this sense, glial cells, especially astrocytes, may have a role in network changes of the nervous system, influencing the retraction of boutons as well as providing a proper perisynaptic environment, thereby affecting the replacement of inputs. Interestingly, the glial reaction does vary between strains of rats and mice. In this sense, we present evidence that C57BL/6J and A/J isogenic mice present different astrocyte reactivity after a peripheral lesion in vivo as well as in vitro, by analyzing primary cell cultures. Such a difference in the glial reaction has a direct influence on in vivo number of pre-synaptic terminals and on in vitro synaptogenesis. (c) 2006 Elsevier B.V. All rights reserved.
Subject: spinal cord
synapse elimination
CNS plasticity
Country: Holanda
Editor: Elsevier Science Bv
Citation: Brain Research. Elsevier Science Bv, v. 1095, n. 35, n. 42, 2006.
Rights: fechado
Identifier DOI: 10.1016/j.brainres.2006.04.021
Date Issue: 2006
Appears in Collections:Unicamp - Artigos e Outros Documentos

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