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Type: Artigo de periódico
Title: Association of severe haemophilia A and factor V Leiden: Report of three cases
Author: Arruda, VR
AnnichinoBizzacchi, JM
Antunes, SV
Costa, FF
Abstract: The clinical severity of haemophilia is usually related to residual clotting factor activity. Reports of factor V deficiency or protein C have been described in haemophilic patients and both are involved in the activated protein C pathway. Recently, the poor response to activated protein C due to factor V Leiden (FQ506) has been associated with an increased risk of thrombosis and its incidence in the normal population is given as 2-7%. We describe three cases of severe haemophilia A heterozygous for factor V Leiden and its influence on phenotype.
Subject: haemophilia
factor V gene
Country: Inglaterra
Editor: Blackwell Science Ltd
Rights: fechado
Identifier DOI: 10.1111/j.1365-2516.1996.tb00011.x
Date Issue: 1996
Appears in Collections:Artigos e Materiais de Revistas Científicas - Unicamp

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