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Type: Artigo de periódico
Title: Association of ABO gene mutations resulting in a rare B subgroup
Author: Sousa, N
Anicchino-Bizzacchi, JM
Leite, EM
Locatelli, MF
Albuquerque, D
Costa, FF
Barjas-Castro, ML
Abstract: Background and Objectives B subgroups are rare and the genetic analysis reported to date has been limited. Materials and Methods Serological and molecular investigations were performed in blood from a B-subgroup donor. Results Red cells did not react with anti-B and anti-AB reagents. However, cells absorbed anti-B. Red cells presented positive reactions with anti-H, and saliva secreted H substance. The molecular study demonstrated a B allele with the substitutions 467C>T, 646T>A, 681G>A, 771C>T, 796C>A, 803G>C, 829G>A and an 0 allele with the sequence of 002. Conclusions It is probable that the presence in exon 7 of some of the 002 substitutions could have weakened the enzymatic activity of the encoded B transferase.
Subject: ABO
B subgroup
blood group
molecular biology
Country: Inglaterra
Editor: Blackwell Publishing Ltd
Rights: fechado
Identifier DOI: 10.1111/j.1423-0410.2005.00583.x
Date Issue: 2005
Appears in Collections:Unicamp - Artigos e Outros Documentos

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