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dc.contributor.CRUESPUniversidade Estadual de Campinaspt_BR
dc.typeArtigo de periódicopt_BR
dc.titleAssociation between the MTHFR A1298C polymorphism and increased risk of acute myeloid leukemia in Brazilian childrenpt_BR
dc.contributor.authorRamos, FJDpt_BR
dc.contributor.authorDe Mello, MPpt_BR
dc.contributor.authorYunes, JApt_BR
dc.contributor.authorMarques-Salles, TDpt_BR
dc.contributor.authorSantos, Npt_BR
dc.contributor.authorBrandalise, SRpt_BR
dc.contributor.authorPombo-de-Oliveira, MSpt_BR
unicamp.author.emailmpombo@inca.gov.brpt_BR
unicamp.authorInst Nacl Canc, CPq, Div Expt Med, BR-20231050 Rio De Janeiro, Brazil Univ Fed Pernambuco, Dept Genet, Recife, PE, Brazil Univ Pernambuco, Inst Ciencias Biol, Dept Biol, Recife, PE, Brazil Univ Pernambuco, Inst Ciencias Biol, Dept Ciencias Fisiol, Recife, PE, Brazil Ctr Infantil Boldrini, Sao Paulo, Brazil Hosp Univ Oswaldo Cruz, Ctr Oncol, Recife, PE, Brazil Fundacao Oswaldo Cruz, Inst Oswaldo Cruz, Dept Genet, Rio De Janeiro, Brazil Univ Estadual Campinas, Ctr Biol Mol & Engn Genet, Sao Paulo, Brazilpt_BR
dc.subjectacute myeloid leukemiapt_BR
dc.subjectMTHFRpt_BR
dc.subjectpolymorphismpt_BR
dc.subjectchildhoodpt_BR
dc.subjectAMLpt_BR
dc.subjectBrazilpt_BR
dc.subject.wosAcute Lymphoblastic-leukemiapt_BR
dc.subject.wosHuman Methylenetetrahydrofolate Reductasept_BR
dc.subject.wosPopulationpt_BR
dc.subject.wosCancerpt_BR
dc.subject.wosC677tpt_BR
dc.subject.wosGenept_BR
dc.description.abstractMethylenetetrahydrofolate reductase ( MTHFR) is an essential enzyme in the metabolism of folate. The presence of polymorphisms that reduce the activity of MTHFR has been linked to the multifactor process of development of acute leukemia. A case control study was conducted on Brazilian children in different regions of the country with the aim of investigating the role of MTHFR C677T and A1298C polymorphisms as risk factors in the development of acute myeloid leukemia (AML). We used the polymerase chain reaction restriction fragment length polymorphism method to genotyping 182 AML and 315 healthy individuals. The genotype 677 CT was associated with decreased risk [ odds ratio ( OR), 0.37; confidence interval (CI) 95%, 0.14 - 0.92], whereas 1298 AC genotype was linked with an increased risk [ OR, 2.90; CI 95%, 1.26 - 6.71] of developing AML in non-white children. Further epidemiological study is needed to unravel the complex multiple gene-environment interactions in the role of the AML leukemogenesis.pt
dc.relation.ispartofLeukemia & Lymphomapt_BR
dc.relation.ispartofabbreviationLeuk. Lymphomapt_BR
dc.publisher.cityAbingdonpt_BR
dc.publisher.countryInglaterrapt_BR
dc.publisherTaylor & Francis Ltdpt_BR
dc.date.issued2006pt_BR
dc.date.monthofcirculationOCTpt_BR
dc.identifier.citationLeukemia & Lymphoma. Taylor & Francis Ltd, v. 47, n. 10, n. 2070, n. 2075, 2006.pt_BR
dc.language.isoenpt_BR
dc.description.volume47pt_BR
dc.description.issuenumber10pt_BR
dc.description.firstpage2070pt_BR
dc.description.lastpage2075pt_BR
dc.rightsfechadopt_BR
dc.rights.licensehttp://journalauthors.tandf.co.uk/permissions/reusingOwnWork.asppt_BR
dc.sourceWeb of Sciencept_BR
dc.identifier.issn1042-8194pt_BR
dc.identifier.wosidWOS:000241581800015pt_BR
dc.identifier.doi10.1080/10428190600800132pt_BR
dc.date.available2014-11-17T00:34:18Z
dc.date.available2015-11-26T17:48:04Z-
dc.date.accessioned2014-11-17T00:34:18Z
dc.date.accessioned2015-11-26T17:48:04Z-
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dc.description.provenanceMade available in DSpace on 2015-11-26T17:48:04Z (GMT). No. of bitstreams: 2 WOS000241581800015.pdf: 89533 bytes, checksum: fd3868e78aeafe2b0c4d3da2725047ff (MD5) WOS000241581800015.pdf.txt: 24185 bytes, checksum: 4c633fbe631434d13a763d010b499e21 (MD5) Previous issue date: 2006en
dc.identifier.urihttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/55057pt_BR
dc.identifier.urihttp://www.repositorio.unicamp.br/handle/REPOSIP/55057
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/55057-
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