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|Type:||Artigo de periódico|
|Title:||Assessment of the value of detecting specific IgA antibodies for the diagnosis of a recently acquired primary Toxoplasma infection|
|Abstract:||Objective To assess the value of detecting IgA antibodies for the diagnosis of a recently acquired primary Toxoplasma infection. Methods IgA antibodies were screened in sera from 87 women with different serological profiles of Toxoplasma gondii IgM and IgG antibodies and Toxoplasma-specific IgG avidity. The IgM and IgG antibodies and the IgG avidity were measured with an automated Vitek Immuno Diagnostic Assay System (VIDAS). Anti-T.gondii IgA was measured with Platelia Toxo IgA TMB kits. Results All 12 sera obtained from women with clinical and/or serological evidence of recently acquired Toxoplasma infection were positive for IgA. In 42 serum samples obtained more than 6 months after T. gondii infection from women wiht no clinical evidence of infection, but who had a positive IgM test and a high IgG avidity index, the IgA-enzyme linked immunosorbent assay (ELISA) test results were positive, negative, and doubtful in 16 (38.1%), 23 (54.85), and 3 (7.1%) sera, respectively. In eight women, IgA was detected in sera collected more than 9 months after the onset of infection. The IgA test result was also positive in 11 of 12 sera (91.7%) obtained from women with no clinical evidence of toxoplasmosis, but who had a positive IgM test and a borderline IgG avidity index. The IgA-ELISA was negative in 21 sera obtained more than 2 years after the onset of T. gondii infection from women with no clinical evidence of toxoplasmosis, but who had a negative IgM test and a positive IgG test. Conclusion These results show that IgA is not a dependable marker for a recently acquired primary Toxoplasma infection. Copyright (C) 2008 John Wiley & sons, Ltd.|
|Editor:||John Wiley & Sons Ltd|
|Appears in Collections:||Artigos e Materiais de Revistas Científicas - Unicamp|
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