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Type: Artigo de periódico
Title: Aspirin inhibits serine phosphorylation of insulin receptor substrate 1 in growth hormone treated animals
Author: Prattali, RR
Barreiro, GC
Caliseo, CT
Fugiwara, FY
Ueno, M
Prada, PO
Velloso, LA
Saad, MJA
Carvalheira, JBC
Abstract: In this study, we demonstrate that pretreatment with aspirin inhibits GH-induced insulin resistance. GH was observed to lead to serine phosphorylation of IRS-1, a phenomenon which was reversed by aspirin in liver, muscle and WAT in parallel with a reduction in JNK activity. In addition, our data show an impairment of insulin activation in the IR/IRSIPI(3)kinase pathway and a reduction in IRS-1 protein levels in rats treated with GH, which was also reversed in the animals pretreated with aspirin. Overall, these results provide new insights into the mechanism of GH-induced insulin resistance. (c) 2005 Published by Elsevier B.V. on behalf of the Federation of European Biochemical Societies.
Subject: insulin
tyrosine phosphorylation
growth hormone
Country: Holanda
Editor: Elsevier Science Bv
Rights: fechado
Identifier DOI: 10.1016/j.febslet.2005.04.075
Date Issue: 2005
Appears in Collections:Artigos e Materiais de Revistas Científicas - Unicamp

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