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Type: Artigo de periódico
Title: Ascorbic acid improves impaired venous and arterial endothelium-dependent dilation in smokers
Author: de Sousa, MG
Yugar-Toledo, JC
Rubira, M
Ferreira-Melo, SE
Plentz, R
Barbieri, D
Consolim-Colombo, F
Irigoyen, MC
Moreno, H
Abstract: Aim: To compare the acute effects of ascorbic acid on vasodilation of veins and arteries in vivo. Methods: Twenty-six healthy non-smokers and 23 healthy moderate smokers were recruited in this study. The dorsal hand vein compliance technique and flow-mediated dilation were used. Dose-response curves to bradykinin and sodium nitroprusside were constructed to test the endothelium-dependent and -independent relaxation before and after acute infusion of ascorbic acid. Results: Smokers had an impaired venodilation with bradykinin compared with non-smokers (68.3%+/- 13.2% vs 93.7%+/- 20.1%, respectively; P < 0.05). Ascorbic acid administration in the dorsal hand vein significantly increased the venodilation with bradykinin in smokers (68.3%+/- 13.2% vs 89.5%+/- 6.3% before and after infusion, respectively; P < 0.05) but not in non-smokers (93.7%+/- 20.1% vs 86.4%+/- 12.4% before and after infusion, respectively). Similarly, the arterial response in smokers had an impaired endothelium-dependent dilation compared with that in non-smokers (8.8%+/- 2.7% vs 15.2%+/- 2.3%, respectively; P < 0.05) and ascorbic acid restored this response in smokers (8.8%+/- 2.7% vs 18.7%+/- 6.5% before and after infusion, respectively; P < 0.05), but no difference was seen in non-smokers (15.2%+/- 2.3% vs 14.0%+/- 4.4% before and after infusion, respectively). The endothelium-independent dilation did not differ in both the groups studied. No important hemodynamic change was detected using the Portapress device. Conclusion: Smokers had impaired endothelium-dependent vasodilation responsiveness in both arterial and venous systems. Ascorbic acid restores this responsiveness in smokers.
Subject: ascorbic acid
vascular endothelium
dorsal hand vein
flow-mediated dilation
Country: China
Editor: Acta Pharmacologica Sinica
Citation: Acta Pharmacologica Sinica. Acta Pharmacologica Sinica, v. 26, n. 4, n. 447, n. 452, 2005.
Rights: fechado
Identifier DOI: 10.1111/j.1745-7254.2005.0069.x
Date Issue: 2005
Appears in Collections:Unicamp - Artigos e Outros Documentos

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