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Type: Artigo de periódico
Title: Antituberculosis macromolecular prodrugs: Part 1: Isoniazid conjugates with poly(ethylene glycol) derivatives
Author: Cruz, ML
Gil, MH
Abstract: The synthesis, elemental and spectrometric analysis of isoniazid conjugates with poly(ethylene glycol) (PEG) were obtained. In the first part of the work, acyl isoniazid, hydroxymethyl isoniazid, and modified poly(ethylene glycol) were synthesized. These compounds were characterized by FTIR, by elemental analysis, and by NMR. To obtain antituberculosis macromolecular prodrugs with sustained delivery, the modified PEG were used as carriers by linking, via end group, either isoniazid or its hydroxymethyl derivative.
Country: EUA
Editor: Technomic Publ Co Inc
Rights: embargo
Date Issue: 1998
Appears in Collections:Artigos e Materiais de Revistas Científicas - Unicamp

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