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|Type:||Artigo de periódico|
|Title:||Antiproliferative effect of Baylis-Hillman adducts and a new phthalide derivative on human tumor cell lines|
De Carvalho, JE
|Abstract:||In this work we report our results concerning the study on the in vitro antiproliferative activity of 18 Baylis-Hillman adducts and some derivatives against a panel of humor tumor cell lines. A brief qualitative structure-activity relationship study indicated that carbon-carbon double bond and the presence of an electron-withdrawing substituent at the aromatic ring are essential for the activity. A quinoline-phthalide derivative has exhibited a potent effect on the proliferation of all cell lines. It is interesting to note their special cytotoxic activity against NCIADR cell line. (c) 2006 Elsevier SAS. All rights reserved.|
|Editor:||Elsevier France-editions Scientifiques Medicales Elsevier|
|Appears in Collections:||Unicamp - Artigos e Outros Documentos|
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