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Type: Artigo de periódico
Title: Antiproliferative effect of Baylis-Hillman adducts and a new phthalide derivative on human tumor cell lines
Author: Kohn, LK
Pavam, CH
Veronese, D
Coelho, F
De Carvalho, JE
Almeida, WP
Abstract: In this work we report our results concerning the study on the in vitro antiproliferative activity of 18 Baylis-Hillman adducts and some derivatives against a panel of humor tumor cell lines. A brief qualitative structure-activity relationship study indicated that carbon-carbon double bond and the presence of an electron-withdrawing substituent at the aromatic ring are essential for the activity. A quinoline-phthalide derivative has exhibited a potent effect on the proliferation of all cell lines. It is interesting to note their special cytotoxic activity against NCIADR cell line. (c) 2006 Elsevier SAS. All rights reserved.
Subject: Baylis-Hillman adducts
antiproliferative activity
Country: França
Editor: Elsevier France-editions Scientifiques Medicales Elsevier
Rights: fechado
Identifier DOI: 10.1016/j.ejmech.2006.03.006
Date Issue: 2006
Appears in Collections:Unicamp - Artigos e Outros Documentos

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