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Type: Artigo de periódico
Title: Analysis of the Growth Pattern of Vero Cells Cultured on Dense and Porous Poly (L-Lactic Acid) Scaffolds
Author: Santos, AR
Barbanti, SH
Duek, EAD
Wada, MLF
Abstract: Poly (L-lactic acid) (PLLA) polymers are the most frequently used substrates for cell culture, tissue regeneration and orthopedic prostheses, mainly because of their atoxic characteristics and good biocompatibility. The objective of this study was to evaluate whether a higher density or different pore diameters (less than 45, 180-250, and 250-350 mu m) would change the growth pattern of cultured cells. The cells were found to adhere to and spread over all PLLA scaffolds studied. The cells also showed similar proliferation on dense and porous PLLA scaffolds, except for PLLA scaffolds with a smaller pore diameter. The cytochemical data showed high metabolic cellular activity on the various substrates. Overall, the results indicated satisfactory cell growth and proliferation on the different PLLA scaffolds studied, especially for those with pore diameters of 180-250 mu m and 250-350 mu m.
Subject: poly (L-lactic acid)
cell culture
tissue engineering
Country: Brasil
Editor: Univ Fed Sao Carlos, Dept Engenharia Materials
Rights: aberto
Date Issue: 2009
Appears in Collections:Artigos e Materiais de Revistas Científicas - Unicamp

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