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Type: | Artigo de periódico |
Title: | Analysis of the Contribution of Nonresident Progenitor Cells and Hematopoietic Cells to Reparative Dentinogenesis Using Parabiosis Model in Mice |
Author: | Frozoni, M Zaia, AA Line, SRP Mina, M |
Abstract: | Introduction: The aim of this study was to analyze the contribution of nonresident progenitor/stem cells and hematopoietic cells to reparative dentinogenesis. Methods: Parabiosis was established between C57BL/6-TgN(ACTbEGFP)10sb/J transgenic mice (GFP+) and C57BL/6 wild-type mice (GFP-) to ensure blood cross-circulation between animals. Reparative dentinogenesis was stimulated by pulp exposures and capping on the first maxillary molar in the GFP- mice. Histologic sections of injured molars from GFP- Mice were analyzed by epifluorescence microscopy to examine the contributions of GFP+ cells (nonresident progenitor cells and hematopoietic cells originating from GFP+ mice) to reparative dentinogenesis. Results: GFP+ cells were detected in close association with reparative dentin formed at the site of pulp exposure in the maxillary first molars of the GFP- mice. Conclusions: The present study suggests the participation of the nonresident progenitor cells and hematopoietic cells in reparative dentinogenesis. (J Endod 2012;38:1214-1219) |
Subject: | Dental pulp green fluorescence protein odontoblast-like cells parabiosis reparative dentinogenesis |
Country: | EUA |
Editor: | Elsevier Science Inc |
Citation: | Journal Of Endodontics. Elsevier Science Inc, v. 38, n. 9, n. 1214, n. 1219, 2012. |
Rights: | fechado |
Identifier DOI: | 10.1016/j.joen.2012.05.016 |
Date Issue: | 2012 |
Appears in Collections: | Unicamp - Artigos e Outros Documentos |
Files in This Item:
File | Description | Size | Format | |
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WOS000308278200011.pdf | 1.1 MB | Adobe PDF | View/Open |
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