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Type: Artigo de periódico
Title: Analysis of the Contribution of Nonresident Progenitor Cells and Hematopoietic Cells to Reparative Dentinogenesis Using Parabiosis Model in Mice
Author: Frozoni, M
Zaia, AA
Line, SRP
Mina, M
Abstract: Introduction: The aim of this study was to analyze the contribution of nonresident progenitor/stem cells and hematopoietic cells to reparative dentinogenesis. Methods: Parabiosis was established between C57BL/6-TgN(ACTbEGFP)10sb/J transgenic mice (GFP+) and C57BL/6 wild-type mice (GFP-) to ensure blood cross-circulation between animals. Reparative dentinogenesis was stimulated by pulp exposures and capping on the first maxillary molar in the GFP- mice. Histologic sections of injured molars from GFP- Mice were analyzed by epifluorescence microscopy to examine the contributions of GFP+ cells (nonresident progenitor cells and hematopoietic cells originating from GFP+ mice) to reparative dentinogenesis. Results: GFP+ cells were detected in close association with reparative dentin formed at the site of pulp exposure in the maxillary first molars of the GFP- mice. Conclusions: The present study suggests the participation of the nonresident progenitor cells and hematopoietic cells in reparative dentinogenesis. (J Endod 2012;38:1214-1219)
Subject: Dental pulp
green fluorescence protein
odontoblast-like cells
reparative dentinogenesis
Country: EUA
Editor: Elsevier Science Inc
Citation: Journal Of Endodontics. Elsevier Science Inc, v. 38, n. 9, n. 1214, n. 1219, 2012.
Rights: fechado
Identifier DOI: 10.1016/j.joen.2012.05.016
Date Issue: 2012
Appears in Collections:Unicamp - Artigos e Outros Documentos

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