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dc.contributor.CRUESPUniversidade Estadual de Campinaspt_BR
dc.typeArtigo de periódicopt_BR
dc.titleAnalysis of surgical margins in oral cancer using in situ fluorescence spectroscopypt_BR
dc.contributor.authorFrancisco, ALNpt_BR
dc.contributor.authorCorrer, WRpt_BR
dc.contributor.authorPinto, CALpt_BR
dc.contributor.authorGoncalves, Jpt_BR
dc.contributor.authorChulam, TCpt_BR
dc.contributor.authorKurachi, Cpt_BR
dc.contributor.authorKowalski, LPpt_BR
unicamp.authorNoronha Francisco, Ana Lucia Univ Estadual Campinas, Sch Dent Piracicaba, Dept Oral Diag, BR-13414018 Piracicaba, SP, Brazilpt_BR
unicamp.authorCorrer, Wagner Rafael Univ Sao Paulo, Sao Carlos Inst Phys, Dept Phys & Mat Sci, BR-13566590 Sao Carlos, SP, Brazilpt_BR
unicamp.authorLopes Pinto, Clovis Antonio AC Camargo Canc Ctr, Dept Pathol, BR-01509900 Sao Paulo, Brazilpt_BR
unicamp.authorGoncalves Filho, Joao Chulam, Thiago Celestino Kowalski, Luiz Paulo AC Camargo Canc Ctr, Dept Head & Neck Surg & Otorhinolaryngol, BR-01509900 Sao Paulo, Brazilpt_BR
unicamp.authorGoncalves Filho, Joao Chulam, Thiago Celestino Kowalski, Luiz Paulo Natl Inst Sci & Technol Oncogenom INCITO, BR-01509900 Sao Paulo, Brazilpt_BR
dc.subjectSquamous cell carcinomapt_BR
dc.subjectFluorescence spectroscopypt_BR
dc.subjectSurgical marginspt_BR
dc.subjectOral cavitypt_BR
dc.subject.wosSquamous-cell Carcinomapt_BR
dc.subject.wosAutofluorescence Characteristicspt_BR
dc.subject.wosPositive Marginspt_BR
dc.subject.wosTumor Marginspt_BR
dc.description.abstractOral cancer is a public health problem with high prevalence in the population. Local tumor control is best achieved by complete surgical resection with adequate margins. A disease-free surgical margin correlates with a lower rate of local recurrence and a higher rate of disease-free survival. Fluorescence spectroscopy is a noninvasive diagnostic tool that can aid in real-time cancer detection. The technique, which evaluates the biochemical composition and structure of tissue fluorescence, is relatively simple, fast and, accurate. Objectives: This study aimed to compare oral squamous cell carcinoma lesions to surgical margins and the mucosa of healthy volunteers by fluorescence spectroscopy. Materials and methods: The sample consisted of 56 individuals, 28 with oral squamous cell carcinoma and 28 healthy volunteers with normal oral mucosa. Thirty six cases (64.3%) were male and the mean age was 60.9 years old. The spectra were classified and compared to histopathology to determine fluorescence efficiency for diagnostic discrimination of tumors. Results: In the analysis of the other cases we observed discrimination between normal mucosa, injury and margins. At two-year follow up, three individuals had local recurrence, and in two cases investigation fluorescence in the corresponding area showed qualitative differences in spectra between the recurrence area and the area without recurrence at the same anatomical site in the same patient. Conclusion: In situ analysis of oral mucosa showed the potential of fluorescence spectroscopy as a diagnostic tool that can aid in discrimination of altered mucosa and normal mucosa. (c) 2014 Elsevier Ltd. All rights
dc.relation.ispartofOral Oncologypt_BR
dc.relation.ispartofabbreviationOral Oncol.pt_BR
dc.publisherElsevier Science Bvpt_BR
dc.identifier.citationOral Oncology. Elsevier Science Bv, v. 50, n. 6, n. 593, n. 599, 2014.pt_BR
dc.sourceWeb of Sciencept_BR
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)pt_BR
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)pt_BR
dc.description.sponsorshipALNF scholarship [140493/2011-5]pt_BR
dc.description.sponsorship1Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)pt_BR
dc.description.sponsorship1Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)pt_BR
dc.description.sponsordocumentnumberFAPESP [98/14270-8, 07/57126-5, 11/10802-1]pt
dc.description.sponsordocumentnumberCNPq [477439/2007-1]pt
dc.description.sponsordocumentnumberALNF scholarship [140493/2011-5]pt
dc.description.provenanceMade available in DSpace on 2014-07-30T13:49:00Z (GMT). No. of bitstreams: 0 Previous issue date: 2014en
dc.description.provenanceMade available in DSpace on 2015-11-26T16:35:12Z (GMT). No. of bitstreams: 0 Previous issue date: 2014en
Appears in Collections:Unicamp - Artigos e Outros Documentos

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