Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/54587
Type: Artigo de periódico
Title: Analysis of pharmaceutical pellets: An approach using near-infrared chemical imaging
Author: Sabin, GP
Breitkreitz, MC
de Souza, AM
da Fonseca, P
Calefe, L
Moffa, M
Poppi, RJ
Abstract: Pharmaceutical pellets are spherical or nearly spherical multi-unit dosage forms designed to optimize pharmacokinetics and pharmacodynamics features of drug release. The distribution of the pharmaceutical ingredients in the layers and core is a very important parameter for appropriate drug release, especially for pellets manufactured by the process of layer gain. Physical aspects of the sample are normally evaluated by Scanning Electron Microscopy (SEM), but it is in many cases unsuitable to provide conclusive chemical information about the distribution of the pharmaceutical ingredients in both layers and core. On the other hand, methods based on spectroscopic imaging can be very promising for this purpose. In this work, a Near-Infrared Chemical Imaging (NIR-CI) method was developed and applied to the analysis of diclophenac sodium pellets. Since all the compounds present in the sample were known in advance. Classical Least Squares (CLS) was used for calculations. The results have shown that the method was capable of providing chemical information about the distribution of the active ingredient and excipients in the core and coating layers and therefore can be complementary to SEM for the pharmaceutical development of pellets. (C) 2011 Elsevier B.V. All rights reserved.
Subject: Pharmaceutical pellets
Chemical image
Near infrared
Chemometrics
Country: Holanda
Editor: Elsevier Science Bv
Rights: fechado
Identifier DOI: 10.1016/j.aca.2011.08.029
Date Issue: 2011
Appears in Collections:Unicamp - Artigos e Outros Documentos

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