Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/54459
Type: Artigo de periódico
Title: AN INVESTIGATION OF THE ELECTRONIC-STRUCTURE OF THE ANTITUMOR DRUG ELLIPTICINE AND ITS DERIVATIVES .1. GEOMETRICAL AM1 STUDY
Author: DANTAS, SO
LAVARDA, FC
GALVAO, DS
LAKS, B
Abstract: Ellipticine and its derivatives are a class of molecules that show antitumor and cytotoxic activity with a multimodal mechanism of action. In this paper we report a preliminary Austin Method One (AM1) study of ellipticine and some molecules derived from it. We have observed a relationship between charge density distribution and biological selectivity. A mechanism that could improve cytotoxic activity is proposed.
Country: Holanda
Editor: Elsevier Science Bv
Rights: fechado
Date Issue: 1992
Appears in Collections:Unicamp - Artigos e Outros Documentos

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