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Type: Artigo de periódico
Title: An easy and stereoselective synthesis of N-Boc-dolaproine via the Baylis-Hillman reaction
Author: Almeida, WP
Coelho, F
Abstract: In this communication we report a stereoselective total synthesis of N-Boc-dolaproine (Dap), an amino acid residue of the antineoplastic pentapeptide Dolastatin 10. Our strategy is based on a Baylis-Hillman reaction between N-Boc-prolinal and methyl acrylate, followed by a diastereoselective double bond hydrogenation and hydrolysis of the ester function. (C) 2003 Elsevier Science Ltd. All rights reserved.
Subject: dolaproine
amino aldehydes
Country: Inglaterra
Editor: Pergamon-elsevier Science Ltd
Rights: fechado
Identifier DOI: 10.1016/S0040-4039(02)02765-X
Date Issue: 2003
Appears in Collections:Artigos e Materiais de Revistas Científicas - Unicamp

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