Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/54327
Type: Artigo de periódico
Title: An approach for the enantioselective synthesis of biologically active furanones from a Morita-Baylis-Hillman adduct
Author: Amarante, GW
Coelho, F
Abstract: Herein, we disclose an approach for the asymmetric synthesis of both enantiomers of an anti-inflammatory furanone. The approach is based on the utilization of a Morita-Baylis-Hillman adduct as starting material and has as key step a selective epoxide-opening/benzylic oxidation mediated by Palladium (II). This sequence afforded an advanced intermediate, which was used to accomplish the total synthesis. Experimental evidences allowed us to suggest a mechanistic proposal for the oxidation Palladium(II)-mediated. (C) 2010 Elsevier Ltd. All rights reserved.
Subject: Morita-Baylis-Hillman
Furanones
Palladium
anti-Inflammatory
Asymmetric synthesis
Country: Inglaterra
Editor: Pergamon-elsevier Science Ltd
Rights: fechado
Identifier DOI: 10.1016/j.tet.2010.06.077
Date Issue: 2010
Appears in Collections:Unicamp - Artigos e Outros Documentos

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