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Type: Artigo de periódico
Title: An amperometric sensor based on hemin adsorbed on silica gel modified with titanium oxide for electrocatalytic reduction and quantification of artemisinin
Author: Reys, JRM
Lima, PR
Cioletti, AG
Ribeiro, AS
de Abreu, FC
Goulart, MOF
Kubota, LT
Abstract: The present work describes the development of an amperometric sensor based on hemin immobilized oil a titanium oxide modified silica toward detection of artemisinin (ARN) in neutral medium at art applied potential of -0.5 V vs. Ag/AgCl. The sensor presented its best performance in 0.1 mol L(-1) phosphate buffer Solution, at pH 7.0. After optimizing the operational conditions, the sensor provided a linear response range for ARN reduction from 50 nmol L(-1) to 1000 nmol L(-1) with a sensitivity, detection and quantification limits of 24.66 A L mol(-1), 15 nmol L(-1) and 52 nmol L(-1), respectively. The proposed sensor showed a stable response for at least 80 successive determinations. The repeatability of the measurements with the sensor and the preparation of a series of electrodes, evaluated in terms of relative standard deviation, were 4.1% and 5.0%, respectively, for n = 10. The developed sensor was applied for the determination of ARN in the crude extracts of A. vulgaris 1, and the average recovery for these samples is 101.4 (+/- 3.1)%. (C) 2008 Elsevier B.V. All rights reserved.
Subject: Artemisinin
Silica gel
Titanium oxide
Amperometric sensor
Country: Holanda
Editor: Elsevier Science Bv
Rights: fechado
Identifier DOI: 10.1016/j.talanta.2008.07.043
Date Issue: 2008
Appears in Collections:Artigos e Materiais de Revistas Científicas - Unicamp

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