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|Type:||Artigo de periódico|
|Title:||Acyloins from Morita-Baylis-Hillman adducts: an alternative approach to the racemic total synthesis of bupropion|
|Abstract:||In this Letter, we describe an easy and straightforward strategy for the preparation of acyloins (alpha-hydroxyketones) from Morita-Baylis-Hillman adducts.. based on a Curtius rearrangement. Different acyloins were obtained with good overall yield (>40% for three steps). To exemplify the synthetic usefulness of this strategy, total synthesis of (+/-)-bupropion, a dopamine, and nor-epinefrine reuptake inhibitor has been accomplished in eight steps with an overall yield of 25%. (C) 2008 Elsevier Ltd. All rights reserved.|
|Editor:||Pergamon-elsevier Science Ltd|
|Appears in Collections:||Artigos e Materiais de Revistas Científicas - Unicamp|
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