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dc.contributor.CRUESPUniversidade Estadual de Campinaspt_BR
dc.typeArtigo de periódicopt_BR
dc.titleAcute inhibition of nitric oxide synthesis induces anxiolysis in the plus maze testpt_BR
dc.contributor.authorFaria, MSpt_BR
dc.contributor.authorMuscara, MNpt_BR
dc.contributor.authorMoreno, Hpt_BR
dc.contributor.authorTeixeira, SApt_BR
dc.contributor.authorDias, HBpt_BR
dc.contributor.authorDeOliveira, Bpt_BR
dc.contributor.authorGraeff, FGpt_BR
dc.contributor.authorDeNucci, Gpt_BR
unicamp.authorUNIMEP, CCBPS, DEPT PHARMACEUT SCI & CLIN ANAL, PIRACICABA, SP, BRAZIL USP, FAC PHILOSOPHY SCI & LETTERS, LAB PSYCHOPHARMACOL, RIBEIRAO PRETO, BRAZILpt_BR
dc.subjectnitric oxide (NO)pt_BR
dc.subjectanxietypt_BR
dc.subjectplus maze, elevatedpt_BR
dc.subjectN-omega-nitro-L-arginine methyl ester (L-NAME)pt_BR
dc.subjectarterial blood pressurept_BR
dc.subjectnitric oxide (NO) synthasept_BR
dc.subjectbrainpt_BR
dc.subject.wosIntercellular Messengerpt_BR
dc.subject.wosPeriaqueductal Graypt_BR
dc.subject.wosNervous-systempt_BR
dc.subject.wosSynthasept_BR
dc.subject.wosAnxietypt_BR
dc.subject.wosReceptorspt_BR
dc.subject.wosMousept_BR
dc.subject.wosMicept_BR
dc.subject.wosRatspt_BR
dc.subject.wosNeuronspt_BR
dc.description.abstractThe involvement of nitric oxide (NO) in anxiety was investigated in rats, using the elevated plus maze test. Acute, but not chronic, systemic treatment with N omega-nitro-L-arginine methyl ester(L-NAME, 10 and 60 mg.kg(-1)), an inhibitor of NO synthase, increased the time spent by the rats in the open arms. Both the acute and chronic treatments with L-NAME inhibited NO synthase in endothelial cells and in the central nervous system, as shown by the increase in mean arterial pressure and decreased NO synthase activity in brain tissue. Chronic treatment with L-NAME also decreased the serum nitrate levels. The anxiolysis induced by acute L-NAME treatment is unlikely to be due to hypertension, since two-kidney one-clip hypertension in non-L-NAME-treated rats failed to significantly change exploratory behaviour in the elevated plus maze. These results indicate that acute inhibition of NO synthesis decreases anxiety in rats. (C) 1997 Elsevier Science B.V.pt
dc.relation.ispartofEuropean Journal Of Pharmacologypt_BR
dc.relation.ispartofabbreviationEur. J. Pharmacol.pt_BR
dc.publisher.cityAmsterdampt_BR
dc.publisher.countryHolandapt_BR
dc.publisherElsevier Science Bvpt_BR
dc.date.issued1997pt_BR
dc.date.monthofcirculation46082pt_BR
dc.identifier.citationEuropean Journal Of Pharmacology. Elsevier Science Bv, v. 323, n. 1, n. 37, n. 43, 1997.pt_BR
dc.language.isoenpt_BR
dc.description.volume323pt_BR
dc.description.issuenumber1pt_BR
dc.description.firstpage37pt_BR
dc.description.lastpage43pt_BR
dc.rightsfechadopt_BR
dc.rights.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policypt_BR
dc.sourceWeb of Sciencept_BR
unicamp.cruespUSPpt_BR
dc.identifier.issn0014-2999pt_BR
dc.identifier.wosidWOS:A1997WR54100005pt_BR
dc.identifier.doi10.1016/S0014-2999(97)00027-7pt_BR
dc.date.available2014-12-16T11:35:29Z
dc.date.available2015-11-26T17:30:15Z-
dc.date.accessioned2014-12-16T11:35:29Z
dc.date.accessioned2015-11-26T17:30:15Z-
dc.description.provenanceMade available in DSpace on 2014-12-16T11:35:29Z (GMT). No. of bitstreams: 1 WOSA1997WR54100005.pdf: 240391 bytes, checksum: 4c5a6a286906174bb135518359e81f45 (MD5) Previous issue date: 1997en
dc.description.provenanceMade available in DSpace on 2015-11-26T17:30:15Z (GMT). No. of bitstreams: 2 WOSA1997WR54100005.pdf: 240391 bytes, checksum: 4c5a6a286906174bb135518359e81f45 (MD5) WOSA1997WR54100005.pdf.txt: 33032 bytes, checksum: 13ed72d72d812a0953b98b31274cf66b (MD5) Previous issue date: 1997en
dc.identifier.urihttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/54209pt_BR
dc.identifier.urihttp://www.repositorio.unicamp.br/handle/REPOSIP/54209
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/54209-
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