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Type: Artigo de periódico
Title: Acute Hepatotoxicity Caused by Enalapril: a Case Report
Author: da Silva, GH
Alves, AVFR
Duques, P
Seva-Pereira, T
Soares, EC
Escanhoela, CAF
Abstract: A case of enalapril-induced acute hepatotoxicity with an unusual morphology is described. This morphology was characterized by macro- and microvesicular steatosis associated with neutrophil infiltration and Mallory bodies, occasionally with satellitosis. These alterations were most abundant in zone 1 of the periportal region, less common in zone 2 and rare in zone 3. There was also confluent periportal necrosis with sinusoidal fibrin deposits associated with intense ductal metaplasia and an infiltrate of inflammatory cells that included plasmocytes and a few eosinophils, as well as focal biliary damage. This morphology, that may be referred as "predominantly periportal steatohepatitis", was distinct from that associated with non-alcohol and alcohol-induced steatohepatitis, both initiated in acinar zone 3 and subsequently extended to other zones.
Subject: ACE inhibitors
acute hepatotoxicity
liver steatosis
Country: Roménia
Editor: Medical Univ Press
Rights: fechado
Date Issue: 2010
Appears in Collections:Unicamp - Artigos e Outros Documentos

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