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Type: Artigo de periódico
Title: Acute effects of pharmacotherapies in blood pressure in normotensive moderate smokers
Author: Martins, LC
Ferreira-Melo, SE
Sabha, M
Coelho, OR
Carlosyugar-Toledo, J
Quinaglia, T
Moreira, MM
Coca, A
Moreno, H
Abstract: This study was designed to evaluate the changes in arterial blood pressure (BP) and heart rate (HR) in moderate smokers during smoking abstinence after 7 days of treatment with bupropion alone, transdermal nicotine or bupropion combined with transdermal nicotine. Twenty-four healthy moderate smokers (12 female/12 male; 40 +/- 7 years) were evaluated randomly on five occasions and their systolic, diastolic, mean arterial blood pressure (MAP) and HR were measured by a Finapres device for 10 h, immediately after smoking interruption. All of the 24 smokers participated on five protocols during 7 days: control group (C)-no drugs; placebo group (PL); bupropion group (BUP) 150-300 mg; transdermal nicotine group (TN) -21 mg; and BUP + TN-nicotine patch. Concomitantly, the subjects were evaluated by ABPM (ambulatory BP monitoring). All of BP parameters monitored shown significant statistical differences in the BUP, TN and BUP + TN groups compared with the controls (p < 0.05), when measured by Finapres. The HR remained unaltered in all of the groups. No significant differences were seen in the BP or HR during the 24-h ABPM. These findings indicate that in moderate smokers, bupropion, transdermal nicotine or bupropion associated with transdermal nicotine caused an elevation in the BP after acute smoking interruption.
Subject: Endothelium
smoking cessation
vascular function
Country: Noruega
Editor: Taylor & Francis As
Rights: fechado
Identifier DOI: 10.1080/08037050903289606
Date Issue: 2009
Appears in Collections:Artigos e Materiais de Revistas Científicas - Unicamp

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