Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/54112
Type: Artigo de periódico
Title: Acid suppression by omeprazole does not affect orally administered metronidazole bioavailability and metabolism in healthy male volunteers
Author: David, FL
Da Silva, CMF
Mendes, FD
Ferraz, JGP
Muscara, MN
Moreno, H
De Nucci, G
Pedrazzoli, J
Abstract: Background: The addition of omeprazole to classical triple therapy for eradication of H. pylori may enhance compliance through reducing ulcer symptoms and side-effects. The aim of this study was to investigate the effects of a 5-day administration of omeprazole on metronidazole pharmacokinetics. Methods: Fourteen healthy male volunteers were selected. The study had an open, randomized, two-period crossover design with a 21-day washout period between the phases. Plasma concentrations of metronidazole and its hydroxy-metabolite were measured by reversed-phase HPLC with ultraviolet detection. Results: Administration of omeprazole did not affect the pharmacokinetic parameters of orally administered metronidazole. Conclusion: Our results indicate that short-term treatment with omeprazole in healthy volunteers does not alter the extent or the rate of metronidazole absorption, and does not affect metronidazole clearance.
Country: Inglaterra
Editor: Blackwell Science Ltd
Rights: fechado
Date Issue: 1998
Appears in Collections:Unicamp - Artigos e Outros Documentos

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