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Type: Artigo de periódico
Title: Abnormalities in body composition and nutritional status in HIV-infected children and adolescents on antiretroviral therapy
Author: Ramalho, LCD
Goncalves, EM
de Carvalho, WRG
Guerra, G
Centeville, M
Aoki, FH
Morcillo, AM
Vilela, MMD
da Silva, MTN
Abstract: This cross-sectional study aimed to compare growth, nutritional status and body composition outcomes between a group of 94 HIV-infected children and adolescents on antiretroviral therapy (ART) and 364 healthy controls, and to evaluate their association with clinical and lifestyle variables within the HIV-infected group. When compared with the control group, HIV patients had higher risk of stunting (odds ratio [OR] 5.33, 95% confidence interval [CI]: 2.83-10.04) and thinness (OR 4.7, 95% CI: 2.44-9.06), higher waist-to-hip ratios (medians 0.89 versus 0.82 for boys and 0.90 versus 0.77 for girls, P < 0.001), and lower prevalence of overweight or obesity (OR 0.33, 95% CI: 0.14-0.78). Protease inhibitor usage was associated with thinness (OR 3.51, 95% CI 1.07-11.44) and lipoatrophy (OR 3.5, 95% CI 1.37-8.95). HIV-infected children on ART showed significant nutritional status and body composition abnormalities, consistent with the severity of vertical HIV infection and the consequences of prolonged ART.
Subject: body composition
nutritional status
children and adolescents
antiretroviral therapy
Country: Inglaterra
Editor: Sage Publications Ltd
Rights: fechado
Identifier DOI: 10.1258/ijsa.2011.010516
Date Issue: 2011
Appears in Collections:Unicamp - Artigos e Outros Documentos

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