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Type: Artigo de periódico
Title: Abnormal production of transforming growth factor beta and interferon gamma by peripheral blood cells of patients with multidrug-resistant pulmonary tuberculosis in Brazil
Author: Castro, AZ
Diaz-Bardalez, BM
Oliveira, EC
Garcia, RC
Afiune, JB
Paschoal, IA
Santos, LMB
Abstract: Objectives. The aim of the present study was to determine the immune response profile that differentiates patients with newly diagnosed (non-treated) pulmonary tuberculosis from multidrug-resistant (MDR) ones, as well as from healthy, tuberculin positive individuals. Methods. Lymphocytes proliferative response to non-specific mitogen (PHA) and PPD were evaluated by H-3 thymidine incorporation and cytokines were quantified using an ELISA assay. Results. Patients with active disease showed a diminished proliferative response to PHA and PPD, white multidrug-resistant patients showed a diminished proliferative response to PHA, but a normal response to PPD. The cytokine production of newly diagnosed patients was characterized by a diminished production of IFN gamma and normal production of transforming growth factor (TGF beta), while MDR patients revealed a normal production of IFN gamma accompanied by an increase in TGF beta. Conclusions. The production of significant amounts of TGF beta in MDR patients leads to a poor immune response and may contribute to the resistance of tuberculosis patients to drugs. (C) 2005 The British Infection Society. Published by Elsevier Ltd. All rights reserved.
Subject: immunosuppression
Mycobacterium tuberculosis
Country: Inglaterra
Editor: W B Saunders Co Ltd
Rights: fechado
Identifier DOI: 10.1016/j.jinf.2004.08.035
Date Issue: 2005
Appears in Collections:Artigos e Materiais de Revistas Científicas - Unicamp

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