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Type: Artigo de periódico
Title: A topological sub-structural approach to the mutagenic activity in dental monomers. 2. Cycloaliphatic epoxides
Author: Gonzalez, MP
Dias, LC
Helguera, AM
Abstract: The topological sub-structural molecular design (TOPS-MODE) approach has been introduced for the study of mutagenic properties. The mutagenicity of 15 dental monomers was studied with this approach obtaining a good quantitative structure-toxicity model. For purposes of comparison, we employed seven different weights in the diagonal entries of the bond matrix in order to select the best TOPS-MODE model. In addition. our best model was compared with a model previously reported in the literature, and proved to be superior. Finally, the TOPS-MODE approach was used to derive the contribution of different fragments to the mutagenicity of all the compounds studied. (C) 2004 Elsevier Ltd. All rights reserved.
Subject: cycloaliphatic epoxides
Country: Inglaterra
Editor: Elsevier Sci Ltd
Rights: fechado
Identifier DOI: 10.1016/j.polymer.2004.04.059
Date Issue: 2004
Appears in Collections:Artigos e Materiais de Revistas Científicas - Unicamp

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