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Type: Artigo de periódico
Title: A simple spectrophotometric procedure for the determination of antimony (III) and (V) in antileishmanial drugs
Author: Rath, S
Jardim, WF
Dorea, JG
Abstract: A spectrophotometric method for the selective determination of antimony (III) and (V) in antileishmanial drugs is described. The procedure is based on the reaction of Sb(III) with bromopyrogallol red (BPR) in neutral solution. As a consequence of the Sb-BPR complex formed, the absorbance of BPR, at 560 nm, decreases proportionally to the amount of Sb(III) in the analyte solution. The calculated apparent molar absorptivity and determination limits are 3.67 x 10(4) L . cm(-1). mol(-1) and 1.65 x 10(-6) mol/L, respectively. Sb(V) is determined after reduction to Sb(III) by iodide. The Sb(V) content determined in ten samples of Glucantime varied from 75.40 +/- 0.97 to 94.47 +/- 1.0 mg/mL. Sb(III) was detected in all samples analyzed, and mean values ranged from 5.19 +/- 0.16 to 10.52 +/- 0.15 mg/mL. The method is suitable for the routine quality control of pharmaceutical formulations.
Editor: Springer Verlag
Rights: fechado
Identifier DOI: 10.1007/s002160050466
Date Issue: 1997
Appears in Collections:Artigos e Materiais de Revistas Científicas - Unicamp

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