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Type: Artigo de periódico
Title: A simple and efficient new approach to the total synthesis of (+/-)-4-amino-3-(4-chlorophenyl)-butyric acid (BACLOFEN)
Author: Coelho, F
deAzevedo, MBM
Boschiero, R
Resende, P
Abstract: Based on the utilization of a [2+2] cycloaddition reaction between dichloroketene and an appropriated olefin as a key step, we describe a new and simple four step approach to the total synthesis of (+/-)-4-amino-3-(4-chlorophenyl)-butyric acid (BACLOFEN), a selective GABA(B) agonist used as antispastic agent.
Editor: Marcel Dekker Inc
Rights: fechado
Identifier DOI: 10.1080/00397919708004109
Date Issue: 1997
Appears in Collections:Artigos e Materiais de Revistas Científicas - Unicamp

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