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Type: Artigo de periódico
Title: A reliable ex vivo invasion assay of human reticulocytes by Plasmodium vivax
Author: Russell, B
Suwanarusk, R
Borlon, C
Costa, FTM
Chu, CS
Rijken, MJ
Sriprawat, K
Warter, L
Koh, EGL
Malleret, B
Colin, Y
Bertrand, O
Adams, JH
D'Alessandro, U
Snounou, G
Nosten, F
Renia, L
Abstract: Currently, there are no reliable RBC invasion assays to guide the discovery of vaccines against Plasmodium vivax, the most prevalent malaria parasite in Asia and South America. Here we describe a protocol for an ex vivo P vivax invasion assay that can be easily deployed in laboratories located in endemic countries. The assay is based on mixing enriched cord blood reticulocytes with matured, trypsin-treated P vivax schizonts concentrated from clinical isolates. The reliability of this assay was demonstrated using a large panel of P vivax isolates freshly collected from patients in Thailand. (Blood. 2011;118(13):e74-e81)
Country: EUA
Editor: Amer Soc Hematology
Rights: fechado
Identifier DOI: 10.1182/blood-2011-04-348748
Date Issue: 2011
Appears in Collections:Artigos e Materiais de Revistas Científicas - Unicamp

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