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|Type:||Artigo de periódico|
|Title:||A pseudobiospecific hollow fiber cartridge for in vitro adsorption of autoantibodies from pathological serum|
|Abstract:||The affinity filtration technique using histidine as a pseudobiospecific ligand immobilized on poly(ethylene vinyl alcohol) hollow fiber membranes (His-PEVA) was used to remove autoantibodies from serum of patients with autoimmune disease. The effects of buffering solution conditions on the efficiency of autoantibodies removal was studied. The removal of anti-dsDNA, anti-SS-A/Ro, anti-Sm, anti-Sm/RNP and anti-cardiolipin autoantibodies present in the serum was investigated, comparing the efficiency between Hepes and Tris-HCl buffers. The results showed the potential of the membrane to remove all the autoantibodies studied. Anti SS-A/Ro was removed more efficiently in Tris-HCl buffer system rather than with the Hepes buffer.|
|Editor:||Brazilian Soc Chemical Eng|
|Appears in Collections:||Unicamp - Artigos e Outros Documentos|
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