Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/534
Type: Artigo de periódico
Title: Effects of methylmercury on male reproductive functions in Wistar rats
Author: SILVA, Daniela A. Fossato da
TEIXEIRA, Carla T.
SCARANO, Wellerson R.
FAVARETO, Ana Paula A.
FERNANDEZ, Carla D. B.
GROTTO, Denise
BARBOSA JR., Fernando
KEMPINAS, Wilma De G.
Abstract: In this study we investigated the effects of subacute exposure to methylmercury (MeHg) on male reproductive functions in rats by means of determination of alterations in structural and functional parameters. Adult male Wistar rats received 0, 0.5, 1.0 or 3.0 mg/kg/body weight/day orally, daily MeHg for 14 days. Sperm motility, the relative sperm count and transit time in the caput/corpus epididymis, were all reduced at all doses. The lowest dose increased the number of sperm head abnormalities; daily sperm production was elevated at the intermediate dose; while at the highest dose there was a decrease in serum testosterone levels and a rise in mercury (Hg) content in reproductive organs, liver and kidneys. In conclusion, MeHg exposure produced damages on male reproductive functions which may be attributed, at least in part, to the reduction in serum testosterone levels. These consequences could potentially result in infertility in rats. (C) 2011 Elsevier Inc. All rights reserved.
Subject: Reproductive toxicity
Methylmercury
Rat
Testosterone
Sperm
Testis
Epididymis
ICP-MS
Country: Inglaterra
Editor: PERGAMON-ELSEVIER SCIENCE LTD
Citation: REPRODUCTIVE TOXICOLOGY, v.31, n.4, p.431-439, 2011
Rights: fechado
Identifier DOI: 10.1016/j.reprotox.2011.01.002
Address: http://apps.isiknowledge.com/InboundService.do?Func=Frame&product=WOS&action=retrieve&SrcApp=EndNote&UT=000291377200008&Init=Yes&SrcAuth=ResearchSoft&mode=FullRecord
http://dx.doi.org/10.1016/j.reprotox.2011.01.002
Date Issue: 2011
Appears in Collections:IB - Artigos e Materiais de Revistas Científicas

Files in This Item:
File Description SizeFormat 
art_SILVA_Effects_of_methylmercury_on_male_reproductive_functions_2011.pdfpublished version1.55 MBAdobe PDFView/Open


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.