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Type: Artigo de periódico
Title: Mathematical modeling and simulation of inulinase adsorption in expanded bed column
Author: Moraes, CC
Mazutti, MA
Rodrigues, MI
Maugeri, F
Kalil, SJ
Abstract: A mathematical model for an expanded bed column was developed to predict breakthrough curves for inulinase adsorption on Streamline SP ion-exchange adsorbent, using a crude fermentative broth with cells as the feedstock. The kinetics and mass transfer parameters were estimated using the PSO (particle swarm optimization) heuristic algorithm. The parameters were estimated for each expansion degree (ED) using three breakthrough curves at initial inulinase concentrations of 65.6U mL(-1). In sequence, the model parameters for an ED of 2.5 were validated using the breakthrough curve at an initial concentration of 114.4 U mL(-1). The applicability of the validated model in process optimization was investigated, using the model as a process simulator and experimental design methodology to optimize the column and process efficiencies. The results demonstrated the usefulness of this methodology for expanded bed adsorption processes. (C) 2009 Elsevier B.V. All rights reserved.
Subject: Inulinase
Expanded bed
Mathematical modeling
Parameter estimation
Experimental design
EBA optimization
Country: Holanda
Editor: Elsevier Science Bv
Rights: fechado
Identifier DOI: 10.1016/j.chroma.2009.03.027
Date Issue: 2009
Appears in Collections:Unicamp - Artigos e Outros Documentos

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