Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/533
Type: Artigo de periódico
Title: Haplotypes of vitamin D receptor modulate the circulating levels of lead in exposed subjects
Author: REZENDE, Vania B.
BARBOSA JR., Fernando
MONTENEGRO, Marcelo F.
SANDRIM, Valeria C.
GERLACH, Raquel F.
TANUS-SANTOS, Jose E.
Abstract: Genetic factors influence whole blood lead (Pb-B) concentrations in lead exposed subjects. This study aimed at examining the combined effects (haplotype analysis) of three polymorphisms (BsmI, ApaI and FokI) in vitamin D receptor (VDR) gene on Pb-B and on the concentrations of lead in plasma (Pb-P), which is more relevant to lead toxicity, in 150 environmentally exposed subjects. Genotypes were determined by RFLP, and Pb-P and Pb-B were determined by inductively coupled plasma mass spectrometry and by graphite furnace atomic absorption spectrometry, respectively. Subjects with the bb (BsmI polymorphism) or ff (FokI polymorphism) genotypes have lower B-Pb than subjects in the other genotype groups. Subjects with the aa (ApaI polymorphism) or ff genotypes have lower P-Pb than subjects in the other genotype groups. Lower Pb-P, Pb-B, and %Pb-P/Pb-B levels were found in subjects with the haplotype combining the a, b, and f alleles for the ApaI, BsmI, and FokI polymorphisms, respectively, compared with the other haplotype groups, thus suggesting that VDR haplotypes modulate the circulating levels of lead in exposed subjects.
Subject: haplotype
polymorphism
plasma lead
toxicogenetics
vitamin D receptor
whole blood lead
Country: Estados Unidos
Editor: SPRINGER
Rights: fechado
Identifier DOI: 10.1007/s00204-007-0231-4
Address: http://dx.doi.org/10.1007/s00204-007-0231-4
http://apps.isiknowledge.com/InboundService.do?Func=Frame&product=WOS&action=retrieve&SrcApp=EndNote&UT=000252539400005&Init=Yes&SrcAuth=ResearchSoft&mode=FullRecord
Date Issue: 2008
Appears in Collections:FCM - Artigos e Materiais de Revistas Científicas

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