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Type: Artigo de periódico
Title: Mammary analogue secretory carcinoma of salivary glands is a lipid-rich tumour, and adipophilin can be valuable in its identification
Author: Mariano, FV
dos Santos, HT
Azanero, WD
da Cunha, IW
Coutinho-Camilo, CM
de Almeida, OP
Kowalski, LP
Altemani, A
Abstract: AimsMammary analogue secretory carcinoma (MASC) of salivary glands shows morphological similarities to milk-secreting mammary epithelial cells. The aim of this study was to analyse the immunohistochemical expression of adipophilin (a component of milk lipid globule membranes) and of proteins related to secretory mechanisms (STAT5a and mammaglobin) in MASC and other salivary tumours. Methods and resultsTen cases of MASC (all with ETV6 translocation) and 83 other salivary carcinomas were studied. In all MASC cases, adipophilin stained numerous large lipid droplets. These droplets were minute in other salivary carcinomas, except for sebaceous carcinoma. Overexpression of STAT5a was detected in all MASC cases, but only occasionally in other carcinomas. Mammaglobin expression occurred frequently in MASC (70% of cases), whereas, in other carcinomas, it was uncommon and limited. Only MASC showed cytoplasmic reactivity for p63, particularly in papillary-cystic areas. Positivity for S100, vimentin and high molecular weight keratin was observed in 100% of MASC cases. ConclusionsMASC is a lipid-rich tumour containing large lipid droplets covered by adipophilin. This finding can be included among its defining immunohistochemical features, and possibly represents lactation-like secretory differentiation. Strong expression of STAT5a and cytoplasmic p63 in MASC reinforces this hypothesis.
Subject: adipophilin
lipid-rich tumour
mammary analogue secretory carcinoma
Country: EUA
Editor: Wiley-blackwell
Citation: Histopathology. Wiley-blackwell, v. 63, n. 4, n. 558, n. 567, 2013.
Rights: fechado
Identifier DOI: 10.1111/his.12192
Date Issue: 2013
Appears in Collections:Unicamp - Artigos e Outros Documentos

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