Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/52947
Type: Artigo de periódico
Title: A Comparative Study of Single-Dose Treatment of Chancroid Using Thiamphenicol versus Azithromycin
Author: Junior, WB
Di Chiacchio, NG
Di Chiacchio, N
Romiti, R
Criado, PR
Velho, PENF
Abstract: A study was conducted in Sao Paulo, Brazil, to compare azithromycin with thiamphenicol for the single-dose treatment of chancroid. In all, 54 men with chancroid were tested. The etiology was determined by clinical characterization and direct bacterioscopy with Gram staining. None of the patients had positive serology or dark-field examination indicating active infection with Treponema pallidum. Genital infections due to Neisseria gonorrhoeae and herpes simplex virus were excluded by polymerase chain reaction testing. For 54 patients with chancroid, cure rates with single-dose treatment were 73% with azithromycin and 89% with thiamphenicol. HIV seropositivity was found to be associated with treatment failure (p=0.001). The treatment failed in all HIV positive patients treated with azithromycin (p=0.002) and this drug should be avoided in these co-infected patients. In the view of the authors, thiamphenicol is the most indicated single-dose regimen for chancroid treatment.
Subject: Azithromycin
chancroid
Haemophilus ducreyi
single dose
thiamphenicol
Country: Brasil
Editor: Contexto
Rights: fechado
Date Issue: 2009
Appears in Collections:Unicamp - Artigos e Outros Documentos

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