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dc.contributor.CRUESPUniversidade Estadual de Campinaspt_BR
dc.typeArtigo de periódicopt_BR
dc.titleLow protein diet confers resistance to the inhibitory effects of interleukin1 beta on insulin secretion in pancreatic isletspt_BR
dc.contributor.authorVieira, ECpt_BR
dc.contributor.authorCarneiro, EMpt_BR
dc.contributor.authorLatorraca, MQpt_BR
dc.contributor.authorDelguingaro-Augusto, Vpt_BR
dc.contributor.authorAmaral, MECpt_BR
dc.contributor.authorBosqueiro, JRpt_BR
dc.contributor.authorBoschero, ACpt_BR
unicamp.authorUniv Estadual Campinas, UNICAMP, Inst Biol, Dept Fisiol & Biofis, BR-13083970 Campinas, SP, Brazil Univ Estadual Paulista, UNESP, Inst Biol, Dept Biol, Bauru, Brazil UFMT, Fac Engfermagem & Nutr, Dept Nutr & Dietet, Cuiaba, MG, Brazilpt_BR
dc.subjectprotein malnutritionpt_BR
dc.subjectpancreatic isletspt_BR
dc.subjectinsulin secretionpt_BR
dc.subjectinterleukin 1 betapt_BR
dc.subjectbeta cellpt_BR
dc.subjectcytokinespt_BR
dc.subject.wosNitric-oxide Synthasept_BR
dc.subject.wosDiabetes-mellituspt_BR
dc.subject.wosRat Isletspt_BR
dc.subject.wosBeta-cellspt_BR
dc.subject.wosL-argininept_BR
dc.subject.wosInterleukin-1-betapt_BR
dc.subject.wosLangerhanspt_BR
dc.subject.wosNitratept_BR
dc.subject.wosSerumpt_BR
dc.subject.wosDnapt_BR
dc.description.abstractHigh protein content in the diet during childhood and adolescence has been associated to the onset insulin-dependent diabetes mellitus. We investigated the effect of interleukin-1 beta (IL-I beta) on insulin secretion, glucose metabolism, and nitrite formation by islets isolated from rats fed with normal protein (NP, 17%) or low protein (LP, 6%) after weaning. Pretreatment of islets with IL-1 beta for 1 h or 34 h inhibited the insulin secretion induced by glucose in both groups, but it was less marked in LP than in NP group. Islets from LP rats exhibited a decreased IL-1 beta -induced nitric oxide (NO) production, lower inhibition of D-[(UC)-C-14]-glucose oxidation to (CO2)-C-14, and less pronounced effect of IL-1 beta on alpha -ketoisocaproic acid-induced insulin secretion than NP islets. However, when the islets were stimulated by high concentrations of K+ the inhibitory effect of IL-1 beta on insulin secretion was not different between groups. In conclusion, protein restriction protects beta -cells of the deleterious effect of IL-1 beta, apparently, by decreasing NO production. The lower NO generation in islets from protein deprived rats may be due to increased free fatty acids oxidation and consequent alteration in Ca2+ homeostasis. (C) 2001 Elsevier Science Inc. All rights reserved.pt
dc.relation.ispartofJournal Of Nutritional Biochemistrypt_BR
dc.relation.ispartofabbreviationJ. Nutr. Biochem.pt_BR
dc.publisher.cityNew Yorkpt_BR
dc.publisher.countryEUApt_BR
dc.publisherElsevier Science Incpt_BR
dc.date.issued2001pt_BR
dc.date.monthofcirculationMAYpt_BR
dc.identifier.citationJournal Of Nutritional Biochemistry. Elsevier Science Inc, v. 12, n. 5, n. 285, n. 291, 2001.pt_BR
dc.language.isoenpt_BR
dc.description.volume12pt_BR
dc.description.issuenumber5pt_BR
dc.description.firstpage285pt_BR
dc.description.lastpage291pt_BR
dc.rightsfechadopt_BR
dc.rights.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policypt_BR
dc.sourceWeb of Sciencept_BR
unicamp.cruespUNESPpt_BR
dc.identifier.issn0955-2863pt_BR
dc.identifier.wosidWOS:000169096600005pt_BR
dc.identifier.doi10.1016/S0955-2863(01)00140-1pt_BR
dc.date.available2014-07-30T13:39:03Z
dc.date.available2015-11-26T18:05:35Z-
dc.date.accessioned2014-07-30T13:39:03Z
dc.date.accessioned2015-11-26T18:05:35Z-
dc.description.provenanceMade available in DSpace on 2014-07-30T13:39:03Z (GMT). No. of bitstreams: 0 Previous issue date: 2001en
dc.description.provenanceMade available in DSpace on 2015-11-26T18:05:35Z (GMT). No. of bitstreams: 0 Previous issue date: 2001en
dc.identifier.urihttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/52742
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/52742-
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