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Type: Artigo de periódico
Title: Low doses of insulin-like growth factor-I improve nitrogen retention and food efficiency in rats with early cirrhosis
Author: Picardi, A
deOliveira, AC
Muguerza, B
Tosar, A
Quiroga, J
CastillaCortazar, I
Santidrian, S
Prieto, J
Abstract: Background/Aims: In order to ascertain whether malnutrition is an early-onset feature of liver cirrhosis and whether the anabolic hormone insulinlike growth factor I (IGF-I) could be useful in the treatment of this complication, we analyzed the nutritional alterations present in rats with early-stage liver cirrhosis and the effects of IGF-I on nutritional parameters in these animals. Methods: After a 24 h fast, a N-15-enriched diet was administered for 5 days to normal control rats and to cirrhotic rats receiving subcutaneous injections of vehicle (Group 1) or IGF-I, 2 mu g . 100 g bw(-1) day(-1), (Group 2) during the 5 experimental days. N-15, a stable N isotope, was measured in biological samples by mass spectrometry. Results: Compared with control rats, Group 1 animals showed significant reductions in N intake and food efficiency (p<0.05, both). In addition, the weight of the gastrocnemius muscle, its total N content and the dietary N content of this muscle were significantly lower in Group 1 than in control animals (p<0.05, all). In rats from Group 2, mean values of N intake, food efficiency, gastrocnemius N content and the amount of dietary N incorporated into this muscle were similar to those in control rats, and (with the exception of gastrocnemius N total content) significantly higher than those in non-treated cirrhotic rats (p<0.05, all). Conclusions: A variety of nutritional disturbances were detected in rats from the early stages of liver cirrhosis. Low doses of IGF-I were found to reverse most of these changes. These results stimulate further studies to determine whether IGF-I might be useful in the correction of the malnutrition present in patients with liver cirrhosis.
Subject: food efficiency
insulin-like growth factor-I (IGF-I)
liver cirrhosis
nitrogen balance
N intake
stable isotope N-15
Country: Dinamarca
Editor: Munksgaard Int Publ Ltd
Rights: fechado
Identifier DOI: 10.1016/S0168-8278(97)80026-8
Date Issue: 1997
Appears in Collections:Artigos e Materiais de Revistas Científicas - Unicamp

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