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Type: Artigo de periódico
Title: 3(2) Factorial design and response surface analysis optimization of N-carboxybutylchitosan synthesis
Author: dos Santos, KSCR
Silva, HSRC
Ferreira, EI
Bruns, RE
Abstract: A 3(2) factorial design investigation to optimize N-carboxybutylchitosan was carried out varying the levulinic acid/chitosan molar ratio between 1.00 and 3.00 and the sodium borohydride/chitosan molar ratio from 0.50 to 1.00. H-1 NMR spectra signals at 1.0 and 2.5 ppm were used to monitor the reaction system. A quadratic model having significant terms for both molar ratios was found for N-carboxybutylchitosan substitution degree whereas a linear model best describes the substitution degree of 5-methylpyrrolidinone chitosan. Maximum N-carboxybutylchitosan and minimum 5-methylpyrrolidinone chitosan substitution degrees occur for levulinic acid/chitosan molar ratios between 2.00 and 3.00 and a 0.50 for sodium borohydride/chitosan molar ratio. (C) 2004 Elsevier Ltd. All rights reserved.
Subject: factorial design
response surface analysis
5-methylpyrrolidinone chitosan
Country: Inglaterra
Editor: Elsevier Sci Ltd
Rights: fechado
Identifier DOI: 10.1016/j.carbpol.2004.08.020
Date Issue: 2005
Appears in Collections:Unicamp - Artigos e Outros Documentos

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