Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/52440
Type: Artigo de periódico
Title: (Java)Protein Dossier: a novel web-based data visualization tool for comprehensive analysis of protein structure
Author: Neshich, G
Rocchia, W
Mancini, AL
Yamagishi, MEB
Kuser, PR
Fileto, R
Baudet, C
Pinto, IP
Montagner, AJ
Palandrani, JF
Krauchenco, JN
Torres, RC
Souza, S
Togawa, RC
Higa, RH
Abstract: (Java)Protein Dossier ((PD)-P-J) is a new concept, database and visualization tool providing one of the largest collections of the physicochemical parameters describing proteins' structure, stability, function and interaction with other macromolecules. By collecting as many descriptors/parameters as possible within a single database, we can achieve a better use of the available data and information. Furthermore, data grouping allows us to generate different parameters with the potential to provide new insights into the sequence-structure-function relationship. In (PD)-P-J, residue selection can be performed according to multiple criteria. (PD)-P-J can simultaneously display and analyze all the physicochemical parameters of any pair of structures, using precalculated structural alignments, allowing direct parameter comparison at corresponding amino acid positions among homologous structures. In order to focus on the physicochemical (and consequently pharmacological) profile of proteins, visualization tools (showing the structure and structural parameters) also had to be optimized. Our response to this challenge was the use of Java technology with its exceptional level of interactivity. (PD)-P-J is freely accessible (within the Gold Sting Suite) at http://sms.cbi.cnptia.embrapa.br, http://mirrors.rcsb.org/SMS, http://trantor.bioc.columbia.edu/SMS and http://www.es.embnet.org/SMS/ (Option: (Java)Protein Dossier).
Country: Inglaterra
Editor: Oxford Univ Press
Rights: aberto
Identifier DOI: 10.1093/nar/gkh480
Date Issue: 2004
Appears in Collections:Artigos e Materiais de Revistas Científicas - Unicamp

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