Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/474
Type: Artigo
Title: Stromal cells play a role in cervical cancer progression mediated by MMP-2 protein
Author: Angelo-Andrade, L. A. de
Morais, S. S.
Fernandes, T.
Pinto, G. A.
Chagas, C. A.
Zeferino, L. C.
Maria-Engler, S. S.
Abstract: Metalloproteinases, especially metal loprotemase-2 (MMP-2), are known for their role in the degradation of the extracellular matrix. Nevertheless, a thorough understanding of MMP-2 expression in neoplastic lesions of the uterine cervix has yet to be accomplished. This study aimed to analyze the MMP-2 expression in cervical intraepithelial neoplasia III (CIN3) and in cervical squamous cell carcinoma, in tumor cells and adjacent stromal cells. MMP-2 expression was assessed by an immunohistochernical technique. MMP-2 expression was greater in the stromal cells of invasive carcinomas than in CIN3 (p < 0.0001). MMP-2 expression in stromal cells correlates with the clinical stage, gradually increasing as the tumor progresses (p = 0.04). This study corroborates that stromal cells play an important role in tumor invasion and progression, mediated by the progressive enhancement of MMP-2 expression from CIN3 to advanced invasive tumor. The intense MMP-2 expression most probably is associated with poor tumor prognosis.
Metalloproteinases, especially metal loprotemase-2 (MMP-2), are known for their role in the degradation of the extracellular matrix. Nevertheless, a thorough understanding of MMP-2 expression in neoplastic lesions of the uterine cervix has yet to be accomplished. This study aimed to analyze the MMP-2 expression in cervical intraepithelial neoplasia III (CIN3) and in cervical squamous cell carcinoma, in tumor cells and adjacent stromal cells. MMP-2 expression was assessed by an immunohistochernical technique. MMP-2 expression was greater in the stromal cells of invasive carcinomas than in CIN3 (p < 0.0001). MMP-2 expression in stromal cells correlates with the clinical stage, gradually increasing as the tumor progresses (p = 0.04). This study corroborates that stromal cells play an important role in tumor invasion and progression, mediated by the progressive enhancement of MMP-2 expression from CIN3 to advanced invasive tumor. The intense MMP-2 expression most probably is associated with poor tumor prognosis
Subject: Neoplasia intraepitelial cervical
Metaloproteinase 2 da matriz
Neoplasias do colo do útero
Células estromais
Country: Canadá
Editor: IROG
Citation: EUROPEAN JOURNAL OF GYNAECOLOGICAL ONCOLOGY, v.29, n.4, p.341-344, 2008
Rights: fechado
Address: https://www.ncbi.nlm.nih.gov/pubmed/18714566
Date Issue: 2008
Appears in Collections:FCM - Artigos e Outros Documentos
CAISM - Artigos e Outros Documentos

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