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|Type:||Artigo de periódico|
|Title:||Stromal cells play a role in cervical cancer progression mediated by MMP-2 protein|
ANGELO-ANDRADE, L. A. de
MORAIS, S. S.
PINTO, G. A.
CHAGAS, C. A.
MARIA-ENGLER, S. S.
ZEFERINO, L. C.
|Abstract:||Metalloproteinases, especially metal loprotemase-2 (MMP-2), are known for their role in the degradation of the extracellular matrix. Nevertheless, a thorough understanding of MMP-2 expression in neoplastic lesions of the uterine cervix has yet to be accomplished. This study aimed to analyze the MMP-2 expression in cervical intraepithelial neoplasia III (CIN3) and in cervical squamous cell carcinoma, in tumor cells and adjacent stromal cells. MMP-2 expression was assessed by an immunohistochernical technique. MMP-2 expression was greater in the stromal cells of invasive carcinomas than in CIN3 (p < 0.0001). MMP-2 expression in stromal cells correlates with the clinical stage, gradually increasing as the tumor progresses (p = 0.04). This study corroborates that stromal cells play an important role in tumor invasion and progression, mediated by the progressive enhancement of MMP-2 expression from CIN3 to advanced invasive tumor. The intense MMP-2 expression most probably is associated with poor tumor prognosis.|
|Subject:||matrix metalloproteinase 2|
cervical intraepithelial neoplasia
|Editor:||I R O G CANADA, INC|
|Appears in Collections:||FCM - Artigos e Outros Documentos|
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