Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/44492
Type: Artigo de periódico
Title: Haptoglobin phenotypes in Brazilian patients with leukemia
Title Alternative: Fenótipos da haptoglobina em pacientes brasileiros com leucemia
Author: Campregher, Paulo Vidal
Lorand-Metze, Irene
Grotto, Helena Zerlotti Wolf
Sonati, Maria de Fatima
Abstract: Haptoglobin (HP) phenotypes were determined in 188 Brazilian patients with the four most common types of leukemia: acute myeloid leukemia (AML), chronic myeloid leukemia (CML), acute lymphoblastic leukemia (ALL) and chronic lymphocytic leukemia (CLL), and were compared to 197 normal controls. We could not confirm the previously suggested increased incidence of the HP1 gene and the HP1-1 phenotype among leukemic patients. A higher frequency of haptoglobinemics (HP0) was observed among patients, in agreement with previous findings.
Os fenótipos de haptoglobina (HP) foram determinados em 188 pacientes brasileiros com os quatro principais tipos de leucemia (LMA, LMC, LLA e LLC) e comparados a 197 controles normais. A existência de associação entre a LMA, a LMC e a LLA e o gene HP-1 e o fenótipo HP 1-1, previamente sugerida na literatura, não foi confirmada no presente estudo. Uma prevalência maior de haptoglobinêmicos (HP0) foi verificada entre os pacientes, em concordância com estudos prévios.
Subject: Fenótipos de haptoglobina
Leucemia
Polimorfismos genéticos
População brasileira
Haptoglobin phenotypes
Leukemia
Genetic polymorphisms
Brazilian population
Editor: Sociedade Brasileira de Patologia ClínicaSociedade Brasileira de PatologiaSociedade Brasileira de Citopatologia
Rights: aberto
Identifier DOI: 10.1590/S1676-24442004000500005
Address: http://dx.doi.org/10.1590/S1676-24442004000500005
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1676-24442004000500005
Date Issue: 1-Oct-2004
Appears in Collections:Artigos e Materiais de Revistas Científicas - Unicamp

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