Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/38634
Type: Artigo de periódico
Title: Comparative study of tissue reactivity to n-butyl-2-cyanoacrylate and nylon monofilament thread on pericranium-cutaneous flaps in rats
Author: Cavazana, William César
Ioshii, Sergio Osamu
Cuman, Roberto Kenji Nakamura
Passeri, Luis Augusto
Abstract: PURPOSE:To study the repair of pericranium-cutaneous flaps fixed with suture anchored in a skull bone tunnel or N-butyl-2-cyanoacrylate adhesive in Wistar rats with emphasis on the cellular inflammatory response and the production of types I and III collagen. METHODS:The operated region in the cephalic region of Wistar rats was removed minutes before euthanasia, fixed in formalin, and subjected to histological preparation. Slides were stained with hematoxylin-eosin and Picrosirius. Standardized counts of polymorphonuclear and mononuclear cells, fibroblasts, and macrophages were performed, and the percentages of types I and III collagen were determined. Data collection occurred on days 3, 7, 14, 21, and 45 postoperatively. A value of p<0.05 was considered statistically significant. RESULTS:Quantitative analysis of the data showed more fibroblasts in the surgical adhesive group than in the nylon monofilament thread groups (p=0.0211). Qualitative analysis showed higher reactivity in the adhesive group, with a predominance of polymorphonuclear cells from days 3-45 and macrophages from days 3-7. The amount of type I collagen exceeded 80% in the treated and control groups at the end of the experiment. CONCLUSIONS:Subperiosteal detachment triggers a cellular inflammatory response that is amplified using soft tissue fixation methods. The adhesive n-butyl-2-cyanoacrylate was more reactive than the nylon monofilament thread anchored in the skull bone tunnel.
Subject: Rhytidoplasty
Cyanoacrylates
Adhesives
Nylons
Wound Healing
Rats
Editor: Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia
Rights: aberto
Identifier DOI: 10.1590/S0102-86502014000400007
Address: http://dx.doi.org/10.1590/S0102-86502014000400007
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502014000400261
Date Issue: 1-Apr-2014
Appears in Collections:Unicamp - Artigos e Outros Documentos

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