Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/38632
Type: Artigo de periódico
Title: Evidence of presynaptic and postsynaptic action of local anesthetics in rats
Author: Braga, Angélica de Fátima de Assunção
Carvalho, Vanessa Henriques
Braga, Franklin Sarmento da Silva
Potério, Gloria Maria Braga
Santos, Filipe Nadir Caparica
Abstract: PURPOSE: To assess the probable actions of ropivacaine, 50% enantiomeric excess bupivacaine mixture (S75-R25) and levobupivacaine on neuromuscular transmission in vitro. METHODS: Thirty rats were distributed into groups (n=5) according to the drug used: ropivacaine, bupivacaine (S75-R25) and levobupivacaine. The concentration used for the three local anesthetics (LA) was 5 µg.mL.-1The following parameters were evaluated: 1) LA effects on membrane potential (MP) and miniature end plate potential (MEPP). A chick biventer cervicis preparation was also used to evaluate LA effects on the contracture response to acetylcholine. RESULTS: LA did not alter MP values and decreased the frequency and amplitude of MEPP. In a chick biventer cervicis preparation, bupivacaine (S75-R25) and levobupivacaine decreased the contracture response to acetylcholine with statistical significance, in comparison to ropivacaine. CONCLUSIONS: In the concentrations used, levobupivacaine and bupivacaine (S75-R25) exhibited presynaptic and postsynaptic actions evidenced by alterations in miniature end plate potentials and contracture response to acetylcholine. Ropivacaine only had a presynaptic action.
Subject: Anesthetics, Local
Bupivacaine
Rats
Editor: Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia
Rights: aberto
Identifier DOI: 10.1590/S0102-86502013001100005
Address: http://dx.doi.org/10.1590/S0102-86502013001100005
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502013001100005
Date Issue: 1-Nov-2013
Appears in Collections:Artigos e Materiais de Revistas Científicas - Unicamp

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