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Type: Artigo de periódico
Title: Immunohistochemical study of androgen, estrogen and progesterone receptors in salivary gland tumors
Author: Ito, Fabio Augusto
Ito, Kazuhiro
Coletta, Ricardo Della
Vargas, Pablo Agustín
Lopes, Márcio Ajudarte
Abstract: The aim of this work was to study the immunohistochemical expression of androgen receptor, estrogen receptor and progesterone receptor in pleomorphic adenomas, Warthin's tumors, mucoepidermoid carcinomas and adenoid cystic carcinomas of salivary glands. A total of 41 pleomorphic adenomas, 30 Warthin's tumors, 30 mucoepidermoid carcinomas and 30 adenoid cystic carcinomas were analyzed, and the immunohistochemical expression of these hormone receptors were assessed. It was observed that all cases were negative for estrogen and progesterone receptors. Androgen receptor was positive in 2 cases each of pleomorphic adenoma, mucoepidermoid carcinoma and adenoid cystic carcinoma. In conclusion, the results do not support a role of estrogen and progesterone in the tumorigenesis of pleomorphic adenomas, Warthin's tumors, mucoepidermoid carcinomas and adenoid cystic carcinomas. However, androgen receptors can play a role in a small set of salivary gland tumors, and this would deserve further studies.
Subject: Receptors, androgen
Receptors, estrogen
Receptors, progesterone
Salivary gland neoplasms
Editor: Sociedade Brasileira de Pesquisa Odontológica - SBPqO
Citation: Brazilian Oral Research. Sociedade Brasileira de Pesquisa Odontológica - SBPqO, v. 23, n. 4, p. 393-398, 2009.
Rights: aberto
Identifier DOI: 10.1590/S1806-83242009000400008
Date Issue: 1-Dec-2009
Appears in Collections:Unicamp - Artigos e Outros Documentos

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