Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/37947
Type: Artigo de periódico
Title: Determination of βS haplotypes in patients with sickle-cell anemia in the state of Rio Grande do Norte, Brazil
Author: Cabral, Cynthia Hatsue Kitayama
Serafim, Édvis Santos Soares
Medeiros, Waleska Rayane Dantas Bezerra de
Fernandes, Thales Allyrio Araújo de Medeiros
Kimura, Elza Miyuki
Costa, Fernando Ferreira
Sonati, Maria de Fátima
Rebecchi, Ivanise Marina Moretti
Medeiros, Tereza Maria Dantas de
Abstract: βS haplotypes were studied in 47 non-related patients with sickle-cell anemia from the state of Rio Grande do Norte, Brazil. Molecular analysis was conducted by PCR/RFLP using restriction endonucleases XmnI, HindIII, HincII and HinfI to analyze six polymorphic sites from the beta cluster. Twenty-seven patients (57.5%) were identified with genotype CAR/CAR, 9 (19.1%) CAR/BEN, 6 (12.8%) CAR/CAM, 1 (2.1%) BEN/BEN, 2 (4.3%) CAR/Atp, 1 (2.1%) BEN/Atp and 1 (2.1%) with genotype Atp/Atp. The greater frequency of Cameroon haplotypes compared to other Brazilian states suggests the existence of a peculiarity of African origin in the state of Rio Grande do Norte.
Subject: haplotypes
β-globin
sickle-cell anemia
Brazilian population
S hemoglobin
Editor: Sociedade Brasileira de Genética
Rights: aberto
Identifier DOI: 10.1590/S1415-47572011005000027
Address: http://dx.doi.org/10.1590/S1415-47572011005000027
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572011000300009
Date Issue: 1-Jan-2011
Appears in Collections:Artigos e Materiais de Revistas Científicas - Unicamp

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