Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/37933
Type: Artigo de periódico
Title: Polymorphism of human haptoglobin and its clinical importance
Author: Wobeto, Vânia Peretti de Albuquerque
Zaccariotto, Tânia Regina
Sonati, Maria de Fátima
Abstract: Haptoglobin (Hp) is a plasma glycoprotein, the main biological function of which is to bind free hemoglobin (Hb) and prevent the loss of iron and subsequent kidney damage following intravascular hemolysis. Haptoglobin is also a positive acute-phase protein with immunomodulatory properties. In humans, the HP locus is polymorphic, with two codominant alleles (HP1 and HP2) that yield three distinct genotypes/phenotypes (Hp1-1, Hp2-1 and Hp2-2). The corresponding proteins have structural and functional differences that may influence the susceptibility and/or outcome in several diseases. This article summarizes the available data on the structure and functions of Hp and the possible effects of Hp polymorphism in a number of important human disorders.
Subject: haptoglobin
hemoglobin
genetic polymorphisms
Editor: Sociedade Brasileira de Genética
Rights: aberto
Identifier DOI: 10.1590/S1415-47572008000400002
Address: http://dx.doi.org/10.1590/S1415-47572008000400002
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572008000400002
Date Issue: 1-Jan-2008
Appears in Collections:Unicamp - Artigos e Outros Documentos

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