Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/37437
Type: Artigo de periódico
Title: Perinatal morbidity and mortality associated with chlamydial infection: a meta-analysis study
Author: Silva, Maria José Penna Maisonnette de Attayde
Florêncio, Gilzandra Lira Dantas
Gabiatti, José Roberto Erbolato
Amaral, Rose Luce do
Eleutério Júnior, José
Gonçalves, Ana Katherine da Silveira
Abstract: OBJECTIVE: To evaluate the effect of Chlamydia trachomatis infection during pregnancy on perinatal morbidity and mortality. METHODS: Systematic review and meta-analysis in an electronic database and manual, combining high sensitivity specific descriptors seeking to answer the research objective. The articles considered to be of high methodological quality (score above 6 on the Newcastle-Ottawa Scale) were assessed by meta-analysis. RESULTS: Summary estimates of 12 studies were calculated by means of Mantel-Haenszel test with 95% confidence interval. It was observed that Chlamydia infection during pregnancy increased risk of preterm labor (relative risk (RR) = 1.35 [1.11, 1.63]), low birth weight (RR = 1.52 [1.24, 1.87]) and perinatal mortality (RR = 1.84 [1.15, 2.94]). No evidence of increased risk was associated with Chlamydia infection in regard to premature rupture of membranes (RR = 1.13 [0.95, 1.34]), abortion and postpartum endometritis (RR = 1.20 [0.65, 2.20] and 0.89 [0.49, 1.61] respectively). CONCLUSION: The diagnosis and treatment of Chlamydia cervicitis during pregnancy can reduce perinatal morbidity and mortality associated with this infection. However, clinical trials are needed to confirm these findings.
Subject: Chlamydia trachomatis
perinatal mortality
morbidity
meta-analysis
Editor: Brazilian Society of Infectious Diseases
Rights: aberto
Identifier DOI: 10.1590/S1413-86702011000600006
Address: http://dx.doi.org/10.1590/S1413-86702011000600006
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702011000600006
Date Issue: 1-Dec-2011
Appears in Collections:Artigos e Materiais de Revistas Científicas - Unicamp

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