Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/364101
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dc.contributor.CRUESPUNIVERSIDADE ESTADUAL DE CAMPINASpt_BR
dc.contributor.authorunicampSteiner-Oliveira, Carolina-
dc.typeArtigopt_BR
dc.titlePhotodynamic therapy and acyclovir in the treatment of recurrent herpes labialis: a controlled randomized clinical trialpt_BR
dc.contributor.authorRamalho, Karen Müller-
dc.contributor.authorCunha, Sandra Ribeiro-
dc.contributor.authorGonçalves, Flavia-
dc.contributor.authorEscudeiro, Gustavo Silva-
dc.contributor.authorSteiner-Oliveira, Carolina-
dc.contributor.authorHorliana, Anna Carolina Rato Tempestini-
dc.contributor.authorEduardo, Carlos de Paula-
dc.subjectAzul de metilenopt_BR
dc.subject.otherlanguageMethylene bluept_BR
dc.description.abstractHerpes Simplex Virus Type 1 (HSV-1) is one of the most widespread infections that can effect the orofacial region. Recurrent infection is considered a life-long oral health problem, leading to pain, discomfort, and social restriction due to esthetic features when active. Effective therapies are needed. This study aimed to compare photodynamic therapy (PDT), Topical Acyclovir (AC), and the association of both in the healing process and self-reported symptomologies of HSV-1 recurrences. Patients were randomly assigned into 3 groups (n = 25): PDT (low-power laser, 660 nm, 40 mW, 120 J/cm2, 4.8 J, 120 s per point) and methylene blue (0.005 %) as photosensitizer; AC (5%); PDT + AC.Data concerning lesion size, healing time, and self-reported healing parameters, such as pain, tingling, and edema were taken every day up to complete healing for all studied groups. There was no significant difference in healing time and pain between groups. AC group showed a significant minor reduction of the lesion compared to the AC-PDT group on day 1. Regarding edema and tingling, the comparison of treatments showed a statistical difference only on day 1, where PDT showed better results. With all the limitations of this study, it can be concluded that only on day 1 PDT showed positive effects in the treatment of herpes lesions in comparison to ACpt_BR
dc.relation.ispartofPhotodiagnosis and photodynamic therapypt_BR
dc.relation.ispartofabbreviationPhotodiagnosis photodyn. ther.pt_BR
dc.publisher.cityAmsterdampt_BR
dc.publisher.countryPaíses Baixospt_BR
dc.publisherElsevierpt_BR
dc.date.issued2021-
dc.date.monthofcirculationMar.pt_BR
dc.language.isoengpt_BR
dc.description.volume33pt_BR
dc.rightsFechadopt_BR
dc.identifier.issn1572-1000pt_BR
dc.identifier.eissn 1873-1597pt_BR
dc.identifier.doi10.1016/j.pdpdt.2020.102093pt_BR
dc.identifier.urlhttps://www.sciencedirect.com/science/article/pii/S1572100020304476pt_BR
dc.description.sponsorshipFUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULO - FAPESPpt_BR
dc.description.sponsordocumentnumber2013/12317-9pt_BR
dc.date.available2021-09-08T15:04:52Z-
dc.date.accessioned2021-09-08T15:04:52Z-
dc.description.provenanceSubmitted by Mariana Aparecida Azevedo (mary1@unicamp.br) on 2021-09-08T15:04:52Z No. of bitstreams: 1 FADE9D53-766A.pdf: 2117644 bytes, checksum: b4a3e9b315e832f870d94f3cbc057bce (MD5)en
dc.description.provenanceMade available in DSpace on 2021-09-08T15:04:52Z (GMT). No. of bitstreams: 1 FADE9D53-766A.pdf: 2117644 bytes, checksum: b4a3e9b315e832f870d94f3cbc057bce (MD5) Previous issue date: 2021en
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/364101-
dc.contributor.departmentDepartamento de Odontologia Infantilpt_BR
dc.contributor.unidadeFaculdade de Odontologia de Piracicabapt_BR
dc.subject.keywordPhotodynamic therapypt_BR
dc.subject.keywordAcyclovirpt_BR
dc.subject.keywordHerpes simplexpt_BR
dc.subject.keywordLaserpt_BR
dc.identifier.sourceFADE9D53-766Apt_BR
dc.creator.orcid0000-0002-0680-2253pt_BR
dc.type.formArtigopt_BR
dc.identifier.articleid102093pt_BR
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