Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/364075
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dc.contributor.CRUESPUNIVERSIDADE ESTADUAL DE CAMPINASpt_BR
dc.contributor.authorunicampTaketa, Thiago Bezerra-
dc.contributor.authorunicampCalais, Guilherme Bedeschi-
dc.contributor.authorunicampBeppu, Marisa Masumi-
dc.typeArtigopt_BR
dc.titleAmino acid-functionalized chitosan beads for in vitro copper ions uptake in the presence of histidinept_BR
dc.contributor.authorTaketa, Thiago B.-
dc.contributor.authorMahl, Cynthia R. A.-
dc.contributor.authorCalais, Guilherme B.-
dc.contributor.authorBeppu, Marisa M.-
dc.subjectDoença de Alzheimerpt_BR
dc.subjectHistidinapt_BR
dc.subjectAdsorçãopt_BR
dc.subject.otherlanguageAlzheimer Diseasept_BR
dc.subject.otherlanguageHistidinept_BR
dc.subject.otherlanguageAdsorptionpt_BR
dc.description.abstractOne of the hallmarks of Alzheimer's Disease (AD) is the anomalous binding involving amyloid-β (Aβ) peptide and metal ions, such as copper, formed through histidine (His) residues. Herein, adsorption experiments were performed to test the in vitro ability of chitosan to uptake copper ions in the presence of histidine. The characterization of the beads was assessed before and after the adsorption process by scanning electron microscope, X-ray diffraction and Fourier-transform infrared spectroscopy. Amino acid functionalization of chitosan-based beads promoted an increase in the copper ions adsorption capacity (2.47 mmol of Cu(II)/gram of adsorbent). Nevertheless, depending on the order of addition of histidine to the system, different adsorption behaviors were observed. The kinetics showed that, once the Cu(II)-His bond was established, functionalized beads were less efficient to capture Cu(II), which promoted a decrease in the overall adsorption capacity. However, when chitosan and histidine were simultaneously added to the Cu(II) solution, there was no decrease in adsorption capacity. To sum up, chitosan-based materials are an interesting model to provide a better understanding on the biomolecules‑copper interactions that occur in AD, as well as a possible chelating agent that can interfere in the bonds between Aβ residues and copper ionspt_BR
dc.relation.ispartofInternational journal of biological macromoleculespt_BR
dc.relation.ispartofabbreviationInt. j. biol. macromol.pt_BR
dc.publisher.cityAmsterdampt_BR
dc.publisher.countryPaíses Baixospt_BR
dc.publisherElsevierpt_BR
dc.date.issued2021-
dc.date.monthofcirculationOct.pt_BR
dc.language.isoengpt_BR
dc.description.volume188pt_BR
dc.description.firstpage421pt_BR
dc.description.lastpage431pt_BR
dc.rightsFechadopt_BR
dc.identifier.issn0141-8130pt_BR
dc.identifier.eissn1879-0003pt_BR
dc.identifier.doi10.1016/j.ijbiomac.2021.08.017pt_BR
dc.identifier.urlhttps://www.sciencedirect.com/science/article/pii/S0141813021016767pt_BR
dc.description.sponsorshipCONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICO - CNPQpt_BR
dc.description.sponsorshipCOORDENAÇÃO DE APERFEIÇOAMENTO DE PESSOAL DE NÍVEL SUPERIOR - CAPESpt_BR
dc.description.sponsorshipFUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULO - FAPESPpt_BR
dc.description.sponsordocumentnumbernão tempt_BR
dc.description.sponsordocumentnumber88882.151600/2017-01pt_BR
dc.description.sponsordocumentnumbernão tempt_BR
dc.date.available2021-08-17T13:46:23Z-
dc.date.accessioned2021-08-17T13:46:23Z-
dc.description.provenanceSubmitted by Mariana Aparecida Azevedo (mary1@unicamp.br) on 2021-08-17T13:46:23Z No. of bitstreams: 1 79108E76-C01A.pdf: 3097403 bytes, checksum: 1e1eece0eb605d5c24b913a228dc4050 (MD5)en
dc.description.provenanceMade available in DSpace on 2021-08-17T13:46:23Z (GMT). No. of bitstreams: 1 79108E76-C01A.pdf: 3097403 bytes, checksum: 1e1eece0eb605d5c24b913a228dc4050 (MD5) Previous issue date: 2021en
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/364075-
dc.contributor.departmentsem informaçãopt_BR
dc.contributor.departmentsem informaçãopt_BR
dc.contributor.departmentDepartamento de Engenharia de Materiais e de Bioprocessospt_BR
dc.contributor.unidadeFaculdade de Engenharia Químicapt_BR
dc.contributor.unidadeFaculdade de Engenharia Químicapt_BR
dc.contributor.unidadeFaculdade de Engenharia Químicapt_BR
dc.identifier.source79108E76-C01Apt_BR
dc.creator.orcid0000-0003-4861-1006pt_BR
dc.creator.orcid0000-0003-4222-1437pt_BR
dc.creator.orcid0000-0001-6519-6970pt_BR
dc.type.formArtigopt_BR
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